MRCKα-H02A
Family ：
Kinase
Catalog No. ：
MRCKα-H02A
Protein ：
MRCKα
UniProt ：
Q5VT25
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
GST
Sequence ：
S2-Q473
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: CDC42BPA
Alias: Serine/threonine-protein kinase MRCK alpha,CDC42-binding protein kinase alpha,DMPK-like alpha,Myotonic dystrophy kinase-related CDC42-binding kinase alpha,MRCK alpha,Myotonic dystrophy protein kinase-like alpha
Uniprot: Q5VT25
Background: Serine/threonine-protein kinase which is an important downstream effector of CDC42 and plays a role in the regulation of cytoskeleton reorganization and cell migration (PubMed:15723050, PubMed:9418861, PubMed:9092543). Regulates actin cytoskeletal reorganization via phosphorylation of PPP1R12C and MYL9/MLC2 (PubMed:21457715). In concert with MYO18A and LURAP1, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration (PubMed:18854160). Phosphorylates: PPP1R12A, LIMK1 and LIMK2 (PubMed:11340065, PubMed:11399775). May play a role in TFRC-mediated iron uptake (PubMed:20188707). In concert with FAM89B/LRAP25 mediates the targeting of LIMK1 to the lamellipodium resulting in its activation and subsequent phosphorylation of CFL1 which is important for lamellipodial F-actin regulation (By similarity). Triggers the formation of an extrusion apical actin ring required for epithelial extrusion of apoptotic cells (PubMed:29162624).
Construct: GST-TEV-GG-MRCKα(S2-Q473)
Expression Host: Insect cell
Purity: 90%
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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