MRE11A-H12B
Family ：
PRRs
Catalog No. ：
MRE11A-H12B
Protein ：
MRE11A
UniProt ：
P49959
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
His/GST
Sequence ：
M1-E411
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: MRE11
Alias: Double-strand break repair protein MRE11,Double-strand break repair protein MRE11A,Meiotic recombination 11 homolog 1,MRE11 homolog 1,Meiotic recombination 11 homolog A,MRE11 homolog A
Uniprot: P49959
Background: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11 (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). RAD50 may be required to bind DNA ends and hold them in close proximity (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289, PubMed:30612738). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888).
Construct: 6His-GST-TEV-GG-MRE11A(M1-E411)
Expression Host: E. coli
Purity: 90%
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
CONTACT US
Telephone：(781)201-9739
Adresse：Block A5, 6 Dongsheng West Road Jiangyin, Jiangsu Province 214437 People’s Republic of China
E-mail：info@wuxibiortus.com
NEWS FEEDS
FOLLOW US
Copyright © 2020 Wuxi Biortus Biosciences Science Co., Ltd 苏ICP备15024653号-1 Power by www.300.cn