E3 ubiquitin-protein ligase
Catalog No. ：
Expression system ：
Symbol/Gene Name: KBTBD8
Alias: Kelch repeat and BTB domain-containing protein 8,T-cell activation kelch repeat protein,TA-KRP
Background: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that acts as a regulator of neural crest specification (PubMed:26399832). The BCR(KBTBD8) complex acts by mediating monoubiquitination of NOLC1 and TCOF1: monoubiquitination promotes the formation of a NOLC1-TCOF1 complex that acts as a platform to connect RNA polymerase I with enzymes responsible for ribosomal processing and modification, leading to remodel the translational program of differentiating cells in favor of neural crest specification (PubMed:26399832).
Construct: (GG)-KBTBD8(A2-L601 end)
Expression Host: Insect cell
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol, 1mM DTT
Supplied as sterile.
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
< 0.01 EU per μg of the protein
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.