KDM6B-H01A
Family ：
Epigenetic
Catalog No. ：
KDM6B-H01A
Protein ：
KDM6B
UniProt ：
O15054
Organism ：
Homo sapiens
Expression system ：
Insect cell
Tag ：
His
Sequence ：
D1141-L1636
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: KDM6B
Alias: Lysine-specific demethylase 6B,JmjC domain-containing protein 3,Jumonji domain-containing protein 3,Lysine demethylase 6B,[histone H3]-trimethyl-L-lysine(27) demethylase 6B
Uniprot: O15054
Background: Histone demethylase that specifically demethylates 'Lys-27' of histone H3, thereby playing a central role in histone code (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Demethylates trimethylated and dimethylated H3 'Lys-27' (PubMed:17825402, PubMed:17851529, PubMed:17713478, PubMed:18003914). Plays a central role in regulation of posterior development, by regulating HOX gene expression (PubMed:17851529). Involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation (PubMed:17825402). Plays a demethylase-independent role in chromatin remodeling to regulate T-box family member-dependent gene expression by acting as a link between T-box factors and the SMARCA4-containing SWI/SNF remodeling complex (By similarity).
Construct: 8His-TEV-KDM6B(D1141-L1636)
Expression Host: Insect cell
Purity: 90%
Formulation: 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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