BP05813-00A
Family ：
Protease and Enzyme
Catalog No. ：
SHMT2-H00A
Protein ：
SHMT2
UniProt ：
P34897
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
S29-H504
Inquiry ：
是
Symbol/Gene Name: SHMT2
Alias: Serine hydroxymethyltransferase, mitochondrial,SHMT,Glycine hydroxymethyltransferase,Serine methylase
Uniprot: P34897
Background: Catalyzes the cleavage of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, an essential intermediate for purine biosynthesis (PubMed:24075985, PubMed:29364879, PubMed:33015733 PubMed:25619277, PubMed:33015733). Serine provides the major source of folate one-carbon in cells by catalyzing the transfer of one carbon from serine to tetrahydrofolate (PubMed:25619277). Contributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism: thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Also required for mitochondrial translation by producing 5,10-methylenetetrahydrofolate; 5,10-methylenetetrahydrofolate providing methyl donors to produce the taurinomethyluridine base at the wobble position of some mitochondrial tRNAs (PubMed:29452640, PubMed:29364879). Associates with mitochondrial DNA (PubMed:18063578). In addition to its role in mitochondria, also plays a role in the deubiquitination of target proteins as component of the BRISC complex: required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).
Construct: SHMT2(S29-H504 end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
CONTACT US
Telephone：(781)201-9739
Adresse：Block A5, 6 Dongsheng West Road Jiangyin, Jiangsu Province 214437 People’s Republic of China
E-mail：info@wuxibiortus.com
NEWS FEEDS
FOLLOW US
Copyright © 2020 Wuxi Biortus Biosciences Science Co., Ltd 苏ICP备15024653号-1 Power by www.300.cn