ORF8-O14B
Family ：
Virus Protein
Catalog No. ：
ORF8-O14B
Protein ：
ORF8
UniProt ：
P0DTC8
Organism ：
Severe acute respiratory syndrome coronavirus 2
Expression system ：
E. coli
Tag ：
His/Flag
Sequence ：
F16-I121
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: ORF8
Alias: ORF8 protein,ORF8,Non-structural protein 8,ns8
Uniprot: P0DTC8
Background: Plays a role in modulating host immune response (PubMed:31986261). May act by down-regulating major histocompability complex class I (MHC-I) (PubMed:34021074). May inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 (PubMed:34177923). Binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors. Contributes to cytokine storm during COVID-19 infection (PubMed:33723527).
Construct: 6His-ORF8(F16-I121)-Flag
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
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