OTUD5-H04A

Family :

DUBs

Catalog No. :

OTUD5-H04A

Protein :

OTUD5

UniProt :

Q96G74

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

Flag

Sequence :

G172-G351

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  OTUD5

Alias:  OTU domain-containing protein 5,Deubiquitinating enzyme A,DUBA

Uniprot: Q96G74

Background: Deubiquitinating enzyme that functions as negative regulator of the innate immune system. Acts via TRAF3 deubiquitination and subsequent suppression of type I interferon (IFN) production. Has peptidase activity towards 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. Can also cleave 'Lys-11'-linked ubiquitin chains (in vitro). Controls neuroectodermal differentiation through cleaving 'Lys-48'-linked ubiquitin chains to counteract degradation of select chromatin regulators such as ARID1A, HDAC2 and HCF1 (PubMed:33523931).

Construct: OTUD5(G172-G351)-Flag

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.