SLC30A10-H154B

Family :

SLC

Catalog No. :

SLC30A10-H154B

Protein :

SLC30A10

UniProt :

Q6XR72

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

8His-MBP,Flag

Sequence :

G2-F485

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  SLC30A10

Alias:  Zinc transporter 10,ZnT-10,Manganese transporter SLC30A10,Solute carrier family 30 member 10

Uniprot: Q6XR72

Background: Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129).

Construct: 8His-MBP-TEV-(GG)-SLC30A10(G2-F485)-Flag

Expression Host: Insect cell

Purity: 90%

Formulation:

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.