SLC46A1-H154B

Family :

SLC

Catalog No. :

SLC46A1-H154B

Protein :

SLC46A1

UniProt :

Q96NT5

Organism :

Homo sapiens

Expression system :

Insect cell

Tag :

8His-MBP,Flag

Sequence :

E2-P459

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  SLC46A1

Alias:  Proton-coupled folate transporter,G21,Heme carrier protein 1,PCFT/HCP1,Solute carrier family 46 member 1

Uniprot: Q96NT5

Background: Proton-coupled high-affinity folate and heme transporter that plays an essential role in iron metabolism (PubMed:30858177, PubMed:32621820). Acts as the main importer of heme in the intestine. Imports also heme in the retina and retinal pigment epithelium, in neurons of the hippocampus, and in the renal epithelial cells (By similarity). Participates therefore in the trafficking of heme and increases intracellular iron content. Mediates also intestinal absorption of folates and their transport from blood to cerebrospinal fluid across the choroid plexus (PubMed:17129779, PubMed:17156779, PubMed:17446347, PubMed:17475902, PubMed:27251438).

Construct: 8His-MBP-TEV-(GG)-SLC46A1(E2-P459)-Flag

Expression Host: Insect cell

Purity: 90%

Formulation:

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.