KRas4B-H00AF

Family :

Ras

Catalog No. :

KRas4B-H00AF

Protein :

KRas4B

UniProt :

P01116

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

biotinylated

Sequence :

M1-M188, Q61R

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  KRAS

Alias:  GTPase KRas, K-Ras 2, Ki-Ras, c-K-ras, c-Ki-ras

Uniprot: P01116

Background: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (PubMed:20949621). Plays an important role in the regulation of cell proliferation (PubMed:23698361, PubMed:22711838). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (PubMed:24623306).

Construct: Biotinylated-Avi-KRas4B(M1-M188 end) (Q61R)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH 7.5), 200 mM NaCl, 20% glycerol

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.