SUMO2-H13A

Family :

Others

Catalog No. :

SUMO2-H13A

Protein :

SUMO2

UniProt :

P61956

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

His/Strep

Sequence :

M1-Y95

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  SUMO2

Alias:  Small ubiquitin-related modifier 2,SUMO-2,HSMT3,SMT3 homolog 2,SUMO-3,Sentrin-2,Ubiquitin-like protein SMT3B,Smt3B

Uniprot: P61956

Background: Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Construct: 6His-strepII-TEV-GG-SUMO2(M1-Y95 end)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.