HLTF-H01A

Family :

E3 ubiquitin-protein ligase

Catalog No. :

HLTF-H01A

Protein :

HLTF

UniProt :

Q14527

Organism :

Homo sapiens

Expression system :

E. coli

Tag :

His

Sequence :

V58-A174

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  HLTF

Alias:  Helicase-like transcription factor,DNA-binding protein/plasminogen activator inhibitor 1 regulator,HIP116,RING finger protein 80,RING-type E3 ubiquitin transferase HLTF,SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 3,Sucrose nonfermenting protein 2-like 3

Uniprot: Q14527

Background: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA.

Construct: 6His-TEV-(GG)-HLTF(V58-A174)

Expression Host: E. coli

Purity: 90%

Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol

Supplied as sterile

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.