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Symbol/Gene Name: HTR5A;OPRK1
Alias: 5-hydroxytryptamine receptor 5A,5-HT-5,5-HT-5A,5-HT5A,Serotonin receptor 5A;Kappa-type opioid receptor,K-OR-1,KOR-1
Uniprot: P47898; P41145
Background: This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.
Construct: Flag-5HT5A(M1-A226)-KOR(L253-R270)-5HT5A(R282-H357 end) (L285R)-3C-10His
Expression Host: Mammalian
Formulation: 25 mM HEPES pH 7.5, 150 mM NaCl, 0.001% (w/v) LMNG, 0.00033% GDN, and 0.0001% CHS
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Please refer to the specific buffer information in the hard copy of CoA.
< 0.01 EU per μg of the protein
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.