ABCB1-H154C

Family :

ABC

Catalog No. :

ABCB1-H154C

Protein :

ABCB1

UniProt :

P08183

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

His,MBP,Flag

Sequence :

D2-Q1280

Assay :

Structure :

Inquiry :

Symbol/Gene Name:  ABCB1

Alias:  ATP-dependent translocase ABCB1,ATP-binding cassette sub-family B member 1,Multidrug resistance protein 1,P-glycoprotein 1,Phospholipid transporter ABCB1,CD243

Uniprot: P08183

Background: Translocates drugs and phospholipids across the membrane (PubMed:8898203, PubMed:2897240, PubMed:9038218). Catalyzes the flop of phospholipids from the cytoplasmic to the exoplasmic leaflet of the apical membrane. Participates mainly to the flop of phosphatidylcholine, phosphatidylethanolamine, beta-D-glucosylceramides and sphingomyelins (PubMed:8898203). Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells (PubMed:2897240, PubMed:9038218).

Construct: 8His-MBP-TEV-(GG)-ABCB1(D2-Q1280 end)-Flag

Expression Host: Mammalian

Purity: 80%

Formulation: 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.02% DDM, 0.002% CHS, 0.25 mM TCEP

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.