ABCB10-H41D

Family :

ABC

Catalog No. :

ABCB10-H41D

Protein :

ABCB10

UniProt :

Q9NRK6

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

Flag-10His

Sequence :

A152-A738

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  ABCB10

Alias:  ATP-binding cassette sub-family B member 10, mitochondrial,ABC-mitochondrial erythroid protein,ABC-me protein,ATP-binding cassette transporter 10,ABC transporter 10 protein,Mitochondrial ATP-binding cassette 2,M-ABC2

Uniprot: Q9NRK6

Background: Catalyzes the export of an unknown physiological substrate from the mitochondrial matrix to the cytosol in an ATP-dependent manner (PubMed:33253225). May also transport the heme analog Zn (II) mesoporphyrin (ZnMP) in an ATP dependent manner but can't export the heme precursor 5-aminolevulinic acid (ALA) from mitochondria (PubMed:33253225). Plays a role in the early step of the heme biosynthetic process during insertion of iron into protoporphyrin IX (PPIX). In turn participates in hemoglobin synthesis and also protects against oxidative stress (PubMed:28808058, PubMed:22085049). In addition may be involved in mitochondrial unfolded protein response (UPRmt) signaling pathway, although ABCB10 probably does not participate in peptide export from mitochondria (PubMed:28315685).

Construct: ABCB10(A152-A738 end)-TEV-Flag-10His

Expression Host: Mammalian

Purity: 95%

Formulation: 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.02% GDN, 0.0002% CHS

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.