ABCC3-H134B

Family :

ABC

Catalog No. :

ABCC3-H134B

Protein :

ABCC3

UniProt :

O15438

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

8His-StrepII/Flag

Sequence :

D2-A1527

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  ABCC3

Alias:  ATP-binding cassette sub-family C member 3,Canalicular multispecific organic anion transporter 2,Multi-specific organic anion transporter D,MOAT-D,Multidrug resistance-associated protein 3

Uniprot: O15438

Background: ATP-dependent transporter of the ATP-binding cassette (ABC) family that bind and hydrolyze ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:11581266, PubMed:15083066, PubMed:10359813). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:15083066, PubMed:11581266). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). Can confers resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:11581266, PubMed:10359813).

Construct: 8His-StrepII-TEV-(GG)-ABCC3(D2-A1527 end)-Flag

Expression Host: Mammalian

Purity: 90%

Formulation:

Supplied as sterile 50 mM HEPES (pH 7.5), 150 mM NaCl, 0.02% GDN, 0.0002% CHS, protease inhibitor cocktail for general use (EDTA free).

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.