ABCC4-H31B_2020 Wuxi Biortus Biosciences Co. Ltd.

ABCC4-H31B

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Family ：

ABC

Catalog No. ：

ABCC4-H31B

Protein ：

ABCC4

UniProt ：

O15439

Organism ：

Homo sapiens

Expression system ：

Mammalian cell

Tag ：

eGFP, Strep II,10His

Sequence ：

M1-L1325

Assay ：

Structure ：

Inquiry ：

是

Product Information

Symbol/Gene Name: ABCC4

Alias: ATP-binding cassette sub-family C member 4,MRP/cMOAT-related ABC transporter,Multi-specific organic anion transporter B,MOAT-B,Multidrug resistance-associated protein 4

Uniprot: O15439

Background: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12883481, PubMed:12523936, PubMed:12835412, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12883481, PubMed:12523936, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:18300232, PubMed:17344354). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685).

Construct: ABCC4(M1-L1325 end) (E1202Q)-3C-eGFP-Strep II-10His

Expression Host: Mammalian

Purity: 85%

Formulation: 50 mM Tris-HCl (pH 8.5), 150 mM KCl, 2 mM DTT, 2 mM MgCl₂, 0.005% (w/v) GDN

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃

Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.