ABCC5-H31E

Family :

ABC

Catalog No. :

ABCC5-H31E

Protein :

ABCC5

UniProt :

O15440

Organism :

Homo sapiens

Expression system :

Mammalian cell

Tag :

eGFP, Strep II,10His

Sequence :

M1-G1437

Assay :

Structure :

Inquiry :

Product Information

Symbol/Gene Name:  ABCC5

Alias:  ATP-binding cassette sub-family C member 5,Multi-specific organic anion transporter C,MOAT-C,Multidrug resistance-associated protein 5,SMRP,pABC11

Uniprot: O15440

Background: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of endogenous metabolites such as cAMP and cGMP, folic acid and N-lactoyl-amino acids (in vitro) (PubMed:10893247, PubMed:15899835, PubMed:25964343, PubMed:17229149, PubMed:12695538, PubMed:12637526). Acts also as a general glutamate conjugate and analog transporter that can limit the brain levels of endogenous metabolites, drugs, and toxins (PubMed:26515061). Confers resistance to the antiviral agent PMEA (PubMed:12695538). Able to transport several anticancer drugs including methotrexate, and nucleotide analogs in vitro, however it does with low affinity, thus the exact role of ABCC5 in mediating resistance still needs to be elucidated (PubMed:10840050, PubMed:15899835, PubMed:12435799, PubMed:12695538). Acts as a heme transporter required for the translocation of cytosolic heme to the secretory pathway (PubMed:24836561). May play a role in energy metabolism by regulating the glucagon-like peptide 1 (GLP-1) secretion from enteroendocrine cells (By similarity).

Construct: ABCC5(M1-G1437 end) (E1355Q)-3C-eGFP-Strep II-10His

Expression Host: Mammalian

Purity: 80%

Formulation: 50mM Tris-HCl (pH 8.0), 150mM KCl, 2mM DTT, 2mM MgCl2, 0.06% digitonin

Please contact us for any concerns or special requirements.

Please refer to the specific buffer information in the hard copy of CoA.

Endotoxin:

< 0.01 EU per μg of the protein

Shipping:

Liquid. It is shipped out with blue ice.

Stability & Storage:

Samples are stable for up to twelve months from date of receipt at -20 to -80

Store it under sterile conditions at -20 to -80. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.