PDK4-H00A
Family ：
Kinase
Catalog No. ：
PDK4-H00A
Protein ：
PDK4
UniProt ：
Q16654
Organism ：
Homo sapiens
Expression system ：
E. coli
Tag ：
No tag
Sequence ：
M1-M411
Assay ：
Structure ：
Inquiry ：
是
Symbol/Gene Name: PDK4
Alias: [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial,Pyruvate dehydrogenase kinase isoform 4
Uniprot: Q16654
Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism.
Construct: PDK4(1-411end)
Expression Host: E. coli
Purity: 90%
Formulation: 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
Supplied as sterile
Please contact us for any concerns or special requirements.
Please refer to the specific buffer information in the hard copy of CoA.
Endotoxin:
< 0.01 EU per μg of the protein
Shipping:
Liquid. It is shipped out with blue ice.
Stability & Storage:
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃
Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Recombinant protein
CONTACT US
Telephone：(781)201-9739
Adresse：Block A5, 6 Dongsheng West Road Jiangyin, Jiangsu Province 214437 People’s Republic of China
E-mail：info@wuxibiortus.com
NEWS FEEDS
FOLLOW US
Copyright © 2020 Wuxi Biortus Biosciences Science Co., Ltd 苏ICP备15024653号-1 Power by www.300.cn