Our Publications




2020 Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma ACS Med. Chem. Lett
2020 Structural Basis for the Inhibition of the RNA-Dependent RNA Polymerase from SARS-CoV-2 by Remdesivir Science
2019 Cryo-EM structures of the human cation-chloride cotransporter KCC1 Science
2019 Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase Nature Communications
2018 Oxidation-resistant and thermostable forms of alpha-1 antitrypsin from Escherichia coli inclusion bodies FEBS Open Bio
2018 Design, synthesis and evaluation of the osimertinib analogue (C-005) as potent EGFR inhibitor against NSCLC Bioorganic & Medicinal Chemistry


Succinate-acetate permease from Citrobacter koseri is an anion channel that unidirectionally translocates acetate

Cell Research

2017 the structure of a small GTPaseRhoA in complex with PDZRhoGEF and the inhibitor HL47 Biotechnol Lett


Determination of osimertinib mesylate by HPLC

Journal of China Pharmaceutical University


Structure of NADP+- bound 7b-hydroxysteroid dehydrogenase reveals two cofactor-binding modes

Acta Crystallographica Section F


MicroRNAs modulate adaption to multiple abiotic stresses in Chlamydomonas reinhardtii

Scientific Reports


An improved preparing process for rivastigmine

Journal of China Pharmaceutical University


Construction and development of an auto regulatory gene expression system in Bacillus subtilis

Microbial Cell Factories


Structural Insights and the Surprisingly Low Mechanical Stability of the Au−S Bond in the Gold-Specific Protein GolB

Journal of the American Chemical Society