a subsidiary company of Shuangliang Group Co. Ltd.
Structural Biology has always been a core strength of Biortus. Here, we employ all three modern technologies for structural studies, X-ray crystallography, Cryo-EM and NMR. We are not only able to provide protein structures for structure-based and fragment-based drug discovery, but also differentiate ourselves from other CROs by working on difficult structures like membrane proteins, large protein complexes, and epitope mapping.
With our in-house Rigaku FR-E+ SuperBright Rotating Anode Coupled with R-axis IV++ Plate Area diffractometer, we could readily collect high resolution data. To increase data collection throughput, Biortus has frequent access to the Shanghai Synchrotron Radiation Facility (SSRF), of which high resolution data sets are collected within minutes.Whilst the SSRF is closed in the summer for maintenance, Biortus would send crystals abroad for data collection at facilities like Advanced Photon Source (APS) in Chicago, the European Synchrotron Radiation Facility (ESRF) in Grenoble, the Canadian Synchrotron Radiation Facility (CSRF), the Super Photon Ring – 8 GeV in Japan and more.
As for cryo-EM, we have access to major high-quality cryo-EM facilities in China containing state-of-the-art cryo-EM hardware like Titan Krios microscope and noiseless Gatan K2 camera. Those facilities are spread all over China from Shanghai (National Centre for Protein Science & iHuman Institute), Beijing Tsinghua University (School of Life Sciences), Zhejiang University to Xiamen University.